cGMP-PKG dependent transcriptome in normal and degenerating retinas: Novel insights into the retinitis pigmentosa pathology. Zhou J, Rasmussen M, Ekström P. Exp Eye Res. 108752, 2021. [doi: 10.1016/j.exer.2021.108752]
Technological advancements to study cellular signaling pathways in inherited retinal degenerative diseases. Roy A, Hilhorst R, Groten J, Paquet-Durand F, Tomar T. Curr Opin Pharmacol. 60:102-110, 2021. [doi: 10.1016/j.coph.2021.07.002]
Cytotoxicity of β-Cyclodextrins in Retinal Explants for Intravitreal Drug Formulations. Prajapati M, Christensen G, Paquet-Durand F, Loftsson T. Molecules 26(5): 1492, 2021. [doi: 10.3390/molecules26051492]
Retinal degeneration: Multilevel protection of photoreceptor and ganglion cell viability and function with the novel PKG inhibitor CN238. Tolone A, Haq W, Fachinger A, Rentsch A, Herberg FW, Schwede F, Paquet-Durand F. bioRxiv 2021.09.10.459762; doi: Repository link
Kinase activity profiling identifies putative downstream targets of cGMP/PKG signaling in inherited retinal neurodegeneration. Roy A, Tolone A, Hilhorst R, Groten J, Tomar T, Paquet Durand F. bioRxiv 2021.08.05.455191; doi: Repository link
Composite solid lipid nanoparticles with hydrogel core for delivering small hydrophilic molecules to the retina: an in vitro study using ARPE-19 and 661W cells. Himawan E, Huang L, Belhadj S, Perez Garcia RO, Paquet Durand F, Schipper N, Buzgo M, Simaite A, Marigo V. bioRxiv 2021.05.24.445543; doi: Repository link
Formulation development and upscaling of lipid nanocapsules as a drug delivery system for a novel cyclic GMP analogue intended for retinal drug delivery. Urimi D, Widenbring R, Perez Garcia RO, Gedda L, Edwards K, Loftsson T, Schipper N. Int J Pharm. 602: 120640, 2021. [doi: 10.1016/j.ijpharm.2021.120640] Repository link
The role of cGMP-signalling and calcium-signalling in photoreceptor cell death: perspectives for therapy development. Das S, Chen Y, Christensen G, Belhadj S, Tolone A, Paquet-Durand F. Pflugers Arch., 2021. [doi: 10.1007/s00424-021-02556-9] PMID: 33864120
Fluorescent detection of PARP activity in unfixed tissue. Belhadj S, Rentsch A, Schwede F, Paquet-Durand F. PLoS One 16(1):e0245369, 2021. [doi: 10.1371/journal.pone.0245369] Repository link
Identification of Novel Substrates for cGMP Dependent Protein Kinase (PKG) through Kinase Activity Profiling to Understand Its Putative Role in Inherited Retinal Degeneration. Roy A, Groten J, Marigo V, Tomar T, Hilhorst R. Int J Mol Sci 22(3):1180, 2021. [doi: 10.3390/ijms22031180] Repository link
Long-term, serum-free cultivation of organotypic mouse retina explants with intact retinal pigment epithelium. Belhadj S, Tolone A, Christensen G, Das S, Chen Y, Paquet-Durand F. J Vis Exp., 2020. [doi: 10.3791/61868]
The cGMP system in normal and degenerating mouse neuroretina: New proteins with cGMP interaction potential identified by a proteomics approach. Rasmussen M, Welinder C, Schwede F, Ekström P. J Neurochem., 2020. [doi: 10.1111/jnc.15251] Repository link
Targeting molecular pathways for the treatment of inherited retinal degeneration. Kutluer M, Huang L, Marigo V. Neural Regen Res. 15(10):1784-1791, 2020. [doi: 10.4103/1673-5374.280303] Repository link
Angiotensin Receptor Blockers in cyclodextrin nanoparticle eye drops: Ocular pharmacokinetics and pharmacologic effect on intraocular pressure. Lorenzo-Soler L, Olafsdottir O B, Garhöfer G, Jansook P, Kristinsdottir I M, Tan A, Loftsson T, Stefánsson E. Acta Ophthalmol., 2020. [doi: 10.1111/aos.14639] Repository link
Stability characterization, kinetics and mechanism of tacrolimus degradation in cyclodextrin solutions. Prajapati M, Eiriksson FF, Loftsson T. Int J Pharm. 586:119579, 2020. [doi: 10.1016/j.ijpharm.2020.119579] PMID: 32599134
Guanylyl Cyclase A/cGMP Signaling Slows Hidden, Age- And Acoustic Trauma-Induced Hearing Loss. Marchetta P, Möhrle D, Eckert P, Reimann K, Wolter S, Tolone A, Lang I, Wolters M, Feil R, Engel J, Paquet-Durand F, Kuhn M, Knipper M, Rüttiger L. Front Aging Neurosci. 12:83, 2020. [doi: 10.3389/fnagi.2020.00083] PMID: 32327991
Cellular mechanisms of hereditary photoreceptor degeneration - Focus on cGMP. Power M, Das S, Schütze K, Marigo V, Ekström P, Paquet-Durand F. Prog Retin Eye Res. 74:100772, 2020. [doi: 10.1016/j.preteyeres.2019.07.005] PMID: 31374251
The cGMP Pathway and Inherited Photoreceptor Degeneration: Targets, Compounds, and Biomarkers. Tolone A, Belhadj S, Rentsch A, Schwede F, Paquet-Durand F. Genes (Basel). 10(6):453, 2019. [doi: 10.3390/genes10060453] PMID: 31207907
Drug delivery to retinal photoreceptors. Himawan E, Ekström P, Buzgo M, Gaillard P, Stefánsson E, Marigo V, Loftsson T, Paquet-Durand F. Drug Discov Today. S1359-6446(18)30511-7, 2019, [doi: 10.1016/j.drudis.2019.03.004] Pubmed
